- Glucose as CREDIT CARD vs Glucose-6-Phosphate as CASH (ready to use)
- Location:
- Hexokinase (Ubiquitous): ALL TISSUE (H con H no va = Hexo con Higado no va)
- Glucokinase: Liver and Pancreas (B-cells)
- Velocity max: Vmax -> High Km in the road = Low Affinity of tires on the road
- GLUcokinase is a GLUtton. It has increased Vmax, because it can not be satisfied)
- Glucose-6-Phosphate feedback inhibition:
- Hexokinase: YES - energy supply
- Glucokinase: NO - storage
- Hexokinase produces a NON-reversible reaction
Monday, February 6, 2012
Hexokinase vs Glucokinase
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