Vitamin K

1. Vitamin K dependant clotting factors: 2, 7, 9, 10 - C, S
2. GLUTAMATE CARBOXILATION by vitamin K
3. Vitamin E TOXICITY INHIBITS vitamin K dependent factors
4. Vitamin K deficiency presents:
• ELEVATED: PTT, PT
• NORMAL: BLEEDING TIME, because platelets are not affected
5. Vitamin K antagonist 
• WARFARIN - Epoxido reductase inhibition (see MIndMap)
6. C and S factors are natural anticoagulants proteins, they prevent excessive coagulation.
7. Warfarin inhibits C and S proteins synthesis and thus produce paradoxical thrombosis.