Drug combination adverse effects

1. ACE inhibitors + Potassium sparing diuretic = HYPERKALEMIA
• every "PRIL" + (amiloride, triamterene, spironolactone)
2. Statins + Fibrates = MYOPATHY and/or HEPATOTOXICITY
• every "STATIN" + gemfibrozil
3. Bile acid binding resins (cholestyramine, colesevelam, colestipol) + Fibrate (gemfibrozil) = GALLSTONES formation
4. Hearing loss combination = OTOTOXICITY
• Aminoglycosides
• Salicilates
• Loop diuretics
• Cisplatine
5. MAO inhibitors + B-adrenergic agonists = HYPERTENSIVE CRISIS
6. MAO inhibitors + SSRI's and/or Meperidine = SEROTONIN SYNDROME